{"id":51142,"date":"2020-04-27T12:36:04","date_gmt":"2020-04-27T12:36:04","guid":{"rendered":"https:\/\/merryjane.com\/off-switch-for-stopping-lsd-trips-developed-by-psychedelics-company\/"},"modified":"2020-04-27T12:36:04","modified_gmt":"2020-04-27T12:36:04","slug":"off-switch-for-stopping-lsd-trips-developed-by-psychedelics-company","status":"publish","type":"post","link":"https:\/\/merryjane.com\/news\/off-switch-for-stopping-lsd-trips-developed-by-psychedelics-company\/","title":{"rendered":"&#8220;Off-Switch&#8221; for Stopping LSD Trips Developed by Psychedelics Company"},"content":{"rendered":"<p>Not every psychedelic experience is a kaleidoscopic thrill ride of epically-fantastic proportions. Some trips feel downright nightmarish, but a fail-safe option may soon arrive to pull people out of unwelcomed <a href=\"https:\/\/merryjane.com\/culture\/what-is-lsd-and-how-does-this-drug-affect-the-mind\" target=\"_blank\" rel=\"noopener\"><u>LSD trips<\/u><\/a>.&nbsp;<\/p>\n<p>Canada\u2019s Mind Medicine Inc., aka MindMed, recently announced a research partnership with the Liechti Laboratory at the University Hospital Basel in Switzerland. Switzerland is not only the <a href=\"https:\/\/merryjane.com\/culture\/bicycle-day-is-a-perfect-childrens-book-about-the-invention-of-lsd-brian-blomerth-interview-2019\" target=\"_blank\" rel=\"noopener\"><u>birthplace of LSD<\/u><\/a>, it\u2019s also home to some of the world\u2019s oldest LSD-assisted psychotherapy clinics, and <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28447622\" rel=\"nofollow noopener\" target=\"_blank\"><u>Dr. Mattias Liechti<\/u><\/a> is considered modern medicine\u2019s foremost expert on LSD in clinical settings. In February, MindMed became one of the <a href=\"https:\/\/merryjane.com\/news\/a-psychedelics-company-is-about-to-list-on-a-public-stock-exchange\" target=\"_blank\" rel=\"noopener\"><u>first psychedelics companies<\/u><\/a> to list on the public Canadian stock exchange.<\/p>\n<p>The partnership will launch <a href=\"https:\/\/www.mindmed.co\/press-releases\/mindmed-acquires-exclusive-license-to-eight-clinical-trials-of-lsd-partners-with-world-leading-psychedelic-research-laboratory-at-university-hospital-basel\" rel=\"nofollow noopener\" target=\"_blank\"><u>Phase II<\/u><\/a> clinical trials for LSD, also known as acid, to treat anxiety. According to a <a href=\"https:\/\/www.prnewswire.com\/news-releases\/psychedelic-pharmaceutical-company-mindmed-develops-lsd-neutralizer-technology-to-shorten-and-stop-lsd-trips-301044965.html\" rel=\"nofollow noopener\" target=\"_blank\"><u>press release<\/u><\/a>, a trip \u201cneutralizer\u201d will also be included in the study, a drug that can counteract the powerful effects of LSD to pull a patient out of a trip quickly and safely.<\/p>\n<p>\u201cOver the past decade, we have amassed the largest collection of clinical trials around LSD; we have been studying the pharmacology and potential medical uses of LSD and other psychedelics for many years in the laboratory, in patients, and in healthy volunteers,\u201d said Dr. Liechti said in a <a href=\"https:\/\/www.mindmed.co\/press-releases\/mindmed-acquires-exclusive-license-to-eight-clinical-trials-of-lsd-partners-with-world-leading-psychedelic-research-laboratory-at-university-hospital-basel\" rel=\"nofollow noopener\" target=\"_blank\"><u>press release<\/u><\/a>. \u201cMindMed is the leading company with a similar mission to ours to use rigorous research and science to create mainstream medicines for neuro-psychiatric conditions. This collaboration now allows us to greatly accelerate our groundbreaking research.\u201d<\/p>\n<p><iframe loading=\"lazy\" allowfullscreen=\"true\" frameborder=\"0\" width=\"640\" height=\"430\" scrolling=\"no\" src=\"https:\/\/merryjane.com\/embed\/gallery\/bitchin-blotter-papers\/1\" ><\/iframe><\/p>\n<p>Neither press release lists <em>what <\/em>the LSD \u201coff-switch\u201d drug will contain, though one does state that MindMed has already filed a US patent for the drug. LSD is known for causing trips that can last from 6 to 12 hours, which can be excessive for many patients who are inexperienced with psychedelics. \u201cChallenging\u201d psychedelic experiences \u2014 a PC term for the dreaded \u201cbad trip\u201d \u2014 could discourage many patients from continuing LSD-assisted psychotherapy. So, if this neutralizing drug works, it could act like an emergency exit for acid sessions that go wrong. Interestingly, another company is working on developing <a href=\"https:\/\/merryjane.com\/news\/want-shrooms-that-never-cause-bad-trips-scientists-are-working-on-it\" target=\"_blank\" rel=\"noopener\">magic mushrooms that never cause bad trips<\/a>, too.<\/p>\n<p>Although we don\u2019t yet know what MindMed\u2019s \u201coff-switch\u201d is made of, we can take some guesses. Scientists still don\u2019t understand how LSD causes hallucination and ego death, but evidence points to the drug\u2019s effects on our serotonin and dopamine transmitters.&nbsp;<\/p>\n<p>\u201cI can say that we have a planned program exploring the use of a range of compounds to be used to treat negative acute experiences with hallucinogens to increase their clinical safe use,\u201d Liechti told <a href=\"https:\/\/newatlas.com\/science\/lsd-off-switch-mindmed-liechti-psychedelic-science\/\" rel=\"nofollow noopener\" target=\"_blank\"><u><em>New Atlas<\/em><\/u><\/a> in an email. \u201cClassically, such treatments included benzodiazepines or haloperidol. Ketanserin has so far been used to investigate the mechanism of action of psychedelic substances.\u201d<\/p>\n<p>Haloperidol blocks dopamine transmission. Ketanserin controls high blood pressure. And benzodiazepines, also known as tranquilizers, usually block serotonin, the neurotransmitter that most closely resembles LSD. Some anecdotes, mainly from self-reports published online by acid users, claim that <a href=\"https:\/\/merryjane.com\/culture\/just-how-long-does-an-acid-trip-last\" target=\"_blank\" rel=\"noopener\"><u>serotonin-blocking drugs<\/u><\/a> like Xanax (alprazolam) can end an LSD trip almost instantly.&nbsp;<\/p>\n<p>However, combining tranquilizers (or haloperidol, or ketanserin) with LSD <a href=\"https:\/\/thecanyonmalibu.com\/blog\/dangers-of-combining-lsd-and-tranquilizers\/\" rel=\"nofollow noopener\" target=\"_blank\"><u>could be deadly<\/u><\/a>, so let\u2019s leave the drug experimentation to the clinical researchers, yeah?&nbsp;<\/p>\n<p><em>Follow Randy Robinson on <\/em><a href=\"https:\/\/twitter.com\/randieseljay\" rel=\"nofollow noopener\" target=\"_blank\"><u><em>Twitter<\/em><\/u><\/a><em>, <\/em><a href=\"https:\/\/www.instagram.com\/randieseljay\/\" rel=\"nofollow noopener\" target=\"_blank\"><u><em>Instagram<\/em><\/u><\/a><em>, and <\/em><a href=\"https:\/\/www.facebook.com\/randieseljay\" rel=\"nofollow noopener\" target=\"_blank\"><u><em>Facebook<\/em><\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Let\u2019s face it: Some experiences on acid suck. But MindMed may have a quick and easy solution, which could aid therapists who administer psychedelics to their patients.<\/p>\n","protected":false},"author":2,"featured_media":51143,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3036],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>&quot;Off-Switch&quot; for Stopping LSD Trips Developed by Psychedelics Company - Merry Jane<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/merryjane.com\/news\/off-switch-for-stopping-lsd-trips-developed-by-psychedelics-company\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;Off-Switch&quot; for Stopping LSD Trips Developed by Psychedelics Company - Merry Jane\" \/>\n<meta property=\"og:description\" content=\"Let\u2019s face it: Some experiences on acid suck. 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